Thelper1 and T helper2 cytokine production patterns in stressed beta2-adrenergic receptor-deficient mice during chlamydia genital infection.

Murine CD4+ T cells have two distinct cytokine secretion patterns to play different functions. We demonstrated that cold-induced stress (CIS) suppresses the immune system leading increased intensity of Chlamydia muridaum in mice. reported beta2-adrenergic receptor (b2-AR) knockout (KO) mice resist chlamydia genital infection. However, profile is not well explored. This study aimed determine production Th1 and Th2 types stressed non-stressed b2-AR KO investigated levels during C. muridarum Significantly cytokines was observed plates pre-coated with anti-CD3/CD28 or presence Con A LPS. decrease IFN-g IL-2, whereas an increase IL-10, IL-13, IL-23 wild-type obtained; however, IL-2 restored Moreover, vitro proliferation CD4 antagonists, ICI 118, 551 stimulated cytokines, agonist, Fenoterol, decreased Th1-type cytokines. Overall, responses are reduced suggesting status polarized toward a response can be by removing from cells.